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Many innovative approaches are entering medical practice in the treatment of diseases that threaten human life or directly affect quality of life. In particular, ozone therapy, which has been gaining popularity recently, is being studied as a supportive method in many medical fields due to its antimicrobial, anti-inflammatory, antioxidant, and immunomodulatory effects [1].
What Is Ozone Therapy?
The treatment of a condition in the body using ozone gas is called ozone therapy. Ozone is a colorless gas composed of three oxygen atoms (O₃). Mechanistically, ozone interacts with lipids to create controlled oxidative stress, which increases the production of antioxidant enzymes (SOD, catalase, GPx), improves tissue oxygenation, and enhances the activity of immune cells [2].
Recent studies indicate that low-dose ozone (typically 10–40 µg/mL) activates the Nrf2/ARE antioxidant pathway, reduces pro-inflammatory cytokines such as TNF-α, and helps restore immune balance [2].
What Conditions Can Ozone Therapy Support?
The most important feature of ozone is its ability to optimize oxygen levels in the body. Many clinicians and researchers consider ozone therapy as a complementary treatment that may provide supportive benefits in the following areas [1, 2]:
- Chronic wounds and skin infections
- Allergies and recurrent vaginal infections
- HPV and viral infections
- Menstrual irregularities and infertility support
- Autoimmune diseases
- Dermatological conditions
- Vascular conditions
- Diabetes management
- Depression and anxiety
- Anti-aging and rejuvenation
- Inflammatory conditions and chronic pain
- Urological disorders and cystitis
- Dental infections
- Migraine
- Cardiovascular and rheumatic diseases
- Lyme disease, Parkinson’s, Alzheimer’s (as adjunct support)
For ozone therapy applications in women’s health, you can visit our Gynecology page.
Who Should Not Receive Ozone Therapy?
Although ozone therapy is considered a safe complementary method, it is not recommended in the following cases:
- Individuals with severe anemia
- Individuals allergic to ozone gas
- Patients who recently had a heart attack
- Patients with recent bleeding
- Individuals with chronic pancreatitis
- Patients using ACE inhibitors for hypertension
- Individuals with coagulation disorders or blood-related conditions
How Is Ozone Therapy Applied?
The application method and number of sessions are determined based on factors such as the course of the disease, the patient’s age, and overall health status. There are two main approaches: systemic and local [1]:
In systemic ozone therapy, 50–200 cc of blood is drawn from the patient and mixed with an ozone-oxygen blend for approximately 10 minutes. The enriched blood is then re-administered intravenously. If intravenous access is not suitable, rectal or vaginal insufflation methods may be used.
In local ozone therapy, the oxygen-ozone mixture is applied to joints, muscles, tendons, skin surfaces, or body cavities in appropriate doses. It can also be injected intramuscularly after mixing with a small amount of blood. The sauna method, frequently used in dermatology, is also preferred for detoxification and weight loss.
A safety analysis covering approximately 5.6 million ozone therapy applications reported a complication rate of 0.0007% [2].